A new in vivo study uncovers how DNA methylation at non-canonical CpG-containing Cdx2 motifs fine-tunes transcription factor binding and enhancer activation during intestinal development. We demonstrate that selective methylation modulates Cdx2 occupancy, ultimately dictating developmental gene expression programs in intestinal epithelial cells. Read more here: https://doi.org/10.1038/s41467-025-56187-0…Continue Reading New Paper: Motif distribution and DNA methylation underlie distinct Cdx2 binding during development and homeostasis
