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Publications

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  1. Lorzadeh, A, Ye, G, Sharma, S, Jadhav, U. Motif distribution and DNA methylation underlie distinct Cdx2 binding during development and homeostasis. Nat Commun. 2025;16 (1):929. doi: 10.1038/s41467-025-56187-0. PubMed PMID:39843425 PubMed Central PMC11754732.
  2. Gaynor, L, Singh, H, Tie, G, Badarinath, K, Madha, S, Mancini, A et al.. Crypt density and recruited enhancers underlie intestinal tumour initiation. Nature. 2025;640 (8057):231-239. doi: 10.1038/s41586-024-08573-9. PubMed PMID:39778708 .
  3. Lorzadeh, A, Ye, G, Sharma, S, Jadhav, U. DNA methylation-dependent and -independent binding of CDX2 directs activation of distinct developmental and homeostatic genes. bioRxiv. 2024; :. doi: 10.1101/2024.02.11.579850. PubMed PMID:38405700 PubMed Central PMC10888781.
  4. Lee, MS, Dennis, C, Naqvi, I, Dailey, L, Lorzadeh, A, Ye, G et al.. Ornithine aminotransferase supports polyamine synthesis in pancreatic cancer. Nature. 2023;616 (7956):339-347. doi: 10.1038/s41586-023-05891-2. PubMed PMID:36991126 PubMed Central PMC10929664.
  5. Lorzadeh, A, Romero-Wolf, M, Goel, A, Jadhav, U. Epigenetic Regulation of Intestinal Stem Cells and Disease: A Balancing Act of DNA and Histone Methylation. Gastroenterology. 2021;160 (7):2267-2282. doi: 10.1053/j.gastro.2021.03.036. PubMed PMID:33775639 PubMed Central PMC8169626.
  6. Zhang, CH, Gao, Y, Jadhav, U, Hung, HH, Holton, KM, Grodzinsky, AJ et al.. Creb5 establishes the competence for Prg4 expression in articular cartilage. Commun Biol. 2021;4 (1):332. doi: 10.1038/s42003-021-01857-0. PubMed PMID:33712729 PubMed Central PMC7955038.
  7. Tsai, PY, Lee, MS, Jadhav, U, Naqvi, I, Madha, S, Adler, A et al.. Adaptation of pancreatic cancer cells to nutrient deprivation is reversible and requires glutamine synthetase stabilization by mTORC1. Proc Natl Acad Sci U S A. 2021;118 (10):. doi: 10.1073/pnas.2003014118. PubMed PMID:33653947 PubMed Central PMC7958225.
  8. Murata, K, Jadhav, U, Madha, S, van Es, J, Dean, J, Cavazza, A et al.. Ascl2-Dependent Cell Dedifferentiation Drives Regeneration of Ablated Intestinal Stem Cells. Cell Stem Cell. 2020;26 (3):377-390.e6. doi: 10.1016/j.stem.2019.12.011. PubMed PMID:32084390 PubMed Central PMC7147146.
  9. Jadhav, U, Manieri, E, Nalapareddy, K, Madha, S, Chakrabarti, S, Wucherpfennig, K et al.. Replicational Dilution of H3K27me3 in Mammalian Cells and the Role of Poised Promoters. Mol Cell. 2020;78 (1):141-151.e5. doi: 10.1016/j.molcel.2020.01.017. PubMed PMID:32027840 PubMed Central PMC7376365.
  10. Jadhav, U, Cavazza, A, Banerjee, KK, Xie, H, O'Neill, NK, Saenz-Vash, V et al.. Extensive Recovery of Embryonic Enhancer and Gene Memory Stored in Hypomethylated Enhancer DNA. Mol Cell. 2019;74 (3):542-554.e5. doi: 10.1016/j.molcel.2019.02.024. PubMed PMID:30905509 PubMed Central PMC6499659.
  11. Jadhav, U, Shivdasani, RA. Dissecting Cell Lineages: From Microscope to Kaleidoscope. Cell. 2019;176 (5):949-951. doi: 10.1016/j.cell.2019.01.054. PubMed PMID:30794779 .
  12. Banerjee, KK, Saxena, M, Kumar, N, Chen, L, Cavazza, A, Toke, NH et al.. Enhancer, transcriptional, and cell fate plasticity precedes intestinal determination during endoderm development. Genes Dev. 2018;32 (21-22):1430-1442. doi: 10.1101/gad.318832.118. PubMed PMID:30366903 PubMed Central PMC6217732.
  13. Malhotra, N, Leyva-Castillo, JM, Jadhav, U, Barreiro, O, Kam, C, O'Neill, NK et al.. RORα-expressing T regulatory cells restrain allergic skin inflammation. Sci Immunol. 2018;3 (21):. doi: 10.1126/sciimmunol.aao6923. PubMed PMID:29500225 PubMed Central PMC5912895.
  14. Saxena, M, Roman, AKS, O'Neill, NK, Sulahian, R, Jadhav, U, Shivdasani, RA et al.. Transcription factor-dependent 'anti-repressive' mammalian enhancers exclude H3K27me3 from extended genomic domains. Genes Dev. 2017;31 (23-24):2391-2404. doi: 10.1101/gad.308536.117. PubMed PMID:29321178 PubMed Central PMC5795785.
  15. Jadhav, U, Saxena, M, O'Neill, NK, Saadatpour, A, Yuan, GC, Herbert, Z et al.. Dynamic Reorganization of Chromatin Accessibility Signatures during Dedifferentiation of Secretory Precursors into Lgr5+ Intestinal Stem Cells. Cell Stem Cell. 2017;21 (1):65-77.e5. doi: 10.1016/j.stem.2017.05.001. PubMed PMID:28648363 PubMed Central PMC5505276.
  16. Jadhav, U, Shivdasani, RA. Natural Selection, Crypt Fitness, and Pol III Dependency in the Intestine. Cell Mol Gastroenterol Hepatol. 2016;2 (6):714-715. doi: 10.1016/j.jcmgh.2016.09.006. PubMed PMID:28174745 PubMed Central PMC5247341.
  17. Kim, TH, Saadatpour, A, Guo, G, Saxena, M, Cavazza, A, Desai, N et al.. Single-Cell Transcript Profiles Reveal Multilineage Priming in Early Progenitors Derived from Lgr5(+) Intestinal Stem Cells. Cell Rep. 2016;16 (8):2053-2060. doi: 10.1016/j.celrep.2016.07.056. PubMed PMID:27524622 PubMed Central PMC5001892.
  18. Jadhav, U, Nalapareddy, K, Saxena, M, O'Neill, NK, Pinello, L, Yuan, GC et al.. Acquired Tissue-Specific Promoter Bivalency Is a Basis for PRC2 Necessity in Adult Cells. Cell. 2016;165 (6):1389-1400. doi: 10.1016/j.cell.2016.04.031. PubMed PMID:27212235 PubMed Central PMC4893000.
  19. Sulahian, R, Chen, J, Arany, Z, Jadhav, U, Peng, S, Rustgi, AK et al.. SOX15 governs transcription in human stratified epithelia and a subset of esophageal adenocarcinomas. Cell Mol Gastroenterol Hepatol. 2015;1 (6):598-609.e6. doi: 10.1016/j.jcmgh.2015.07.009. PubMed PMID:26516633 PubMed Central PMC4620585.
  20. Jadhav, U, Harris, RM, Jameson, JL. Hypogonadotropic hypogonadism in subjects with DAX1 mutations. Mol Cell Endocrinol. 2011;346 (1-2):65-73. doi: 10.1016/j.mce.2011.04.017. PubMed PMID:21672607 PubMed Central PMC3185185.
  21. Jadhav, U, Jameson, JL. Steroidogenic factor-1 (SF-1)-driven differentiation of murine embryonic stem (ES) cells into a gonadal lineage. Endocrinology. 2011;152 (7):2870-82. doi: 10.1210/en.2011-0219. PubMed PMID:21610156 PubMed Central PMC3192422.
  22. Ezhilarasan, R, Jadhav, U, Mohanam, I, Rao, JS, Gujrati, M, Mohanam, S et al.. The hemopexin domain of MMP-9 inhibits angiogenesis and retards the growth of intracranial glioblastoma xenograft in nude mice. Int J Cancer. 2009;124 (2):306-15. doi: 10.1002/ijc.23951. PubMed PMID:18942717 PubMed Central PMC2814063.
  23. Jadhav, U, Ezhilarasan, R, Vaughn, SF, Berhow, MA, Mohanam, S. Dietary isothiocyanate iberin inhibits growth and induces apoptosis in human glioblastoma cells. J Pharmacol Sci. 2007;103 (2):247-51. doi: 10.1254/jphs.sc0060148. PubMed PMID:17310076 .
  24. Jadhav, U, Ezhilarasan, R, Vaughn, SF, Berhow, MA, Mohanam, S. Iberin induces cell cycle arrest and apoptosis in human neuroblastoma cells. Int J Mol Med. 2007;19 (3):353-61. . PubMed PMID:17273780 PubMed Central PMC2435066.
  25. Jadhav, U, Mohanam, S. Response of neuroblastoma cells to ionizing radiation: modulation of in vitro invasiveness and angiogenesis of human microvascular endothelial cells. Int J Oncol. 2006;29 (6):1525-31. . PubMed PMID:17088992 PubMed Central PMC2441915.
  26. Jadhav, U, Chigurupati, S, Lakka, SS, Mohanam, S. Inhibition of matrix metalloproteinase-9 reduces in vitro invasion and angiogenesis in human microvascular endothelial cells. Int J Oncol. 2004;25 (5):1407-14. . PubMed PMID:15492832 .